Purity 99% Ibrutinib Powder-Jinan Zhenxuan Trading Co., Ltd.

Purity 99% Ibrutinib Powder

Purity 99% Ibrutinib powder cas 936563-96-1 is an inhibitor of Bruton tyrosine kinase (BTK) for the treatment of chronic lymphoblastic leukemia (CLL) and sleeve cell lymphoma (MCL).

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Product introduction：

CAS: 936563-96-1

MF: C₂₅H₂₄N₆O₂

Loss on drying: ≤1.0%

Purity: ≥99.0%

Description: Purity 99% Ibrutinib powder cas 936563-96-1 is an inhibitor of Bruton tyrosine kinase (BTK) for the treatment of chronic lymphoblastic leukemia (CLL) and sleeve cell lymphoma (MCL).

Application:

1. Purity 99% Ibrutinib powder cas 936563-96-1 is used for Chronic graft-versus-host (cGVHD) disease after failure of one or more prior lines of systemic therapy.

2. Chronic lymphocytic leukemia (CLL) who have received at least one prior therapy.

3. Mantle cell lymphoma (MCL) who have received at least one prior therapy.

4. Marginal zone lymphoma (MZL) who require systemic therapy and have received at least one prior anti-CD20-based therapy.

5. Waldenstrom's macroglobulinemia.

Certificate of analysis

Items	Standard		Results
Description	White To off-white powder		White powder
Solubility	Soluble in tetrahydrofuran, slightly soluble in methanol, dichloromethane or acetonitrile, slightly soluble in toluene, practically insoluble in water		Conforms
Identification	Should be accaordence with reference		Conforms
Water	≤1.5%		0.05%
Solvent residue	THF≤720ppm		400ppm
	Methylbenzene≤890ppm		not detected
	Methanol≤3000ppm		30ppm
	Dichloromethane≤600ppm		250ppm
	Ethyl acetate≤5000ppm		not detected
Residue on ignition	≤0.2%		0.07%
Heavy metals	≤20ppm		Conforms
Related substances	Single impurity	≤0.2%	0.04%
	Total impurity	≤2.0%	0.27%
Assay	97.0%—103.0%		100.4%

Purity 99% Ibrutinib powder cas 936563-96-1 is an inhibitor of Bruton tyrosine kinase (BTK) for the treatment of chronic lymphoblastic leukemia (CLL) and sleeve cell lymphoma (MCL).